Athiri is the oldest Greek white wine grape variety, indigenous to the Cretan vineyard. “Thireos oenos” has been known since the 2nd century C.E. A further reference by Ptochoprodromos in the 13th (or 14th) century C.E. to “Cretan Athyrin” hints at the cultivation of Athiri in Crete in earlier centuries. It is believed that Athiri was already known in Classical times under the name “Thiraiki” and was used during the Middle Ages as the main part of the Cretan Malvasia blend. According to Logothetis (1975), the name of the grape variety derives etymologically either from “thirea grapes” (thirea>thiri>athiri); or from the verb athyrein (αθύριν) which in Greek means to alter, to vary. Today, it is cultivated in a surface area of 1200-1500 ha in almost all viticultural regions extending from Macedonia to Crete (Dodecanese, Cyclades, Thrace, Central Greece, Peloponnese, Ionian islands).