Grapevine variety Dempina is cultivated in the greater viticultural area of Zitsa of Prefecture of Ioannina, with a surface area of 550 ha. Dempina is an old autochthonous variety of Epirus dating back to the 16th century and it owes its name to the village Ntampeni located between Kastoria and Koritsa. Due to the fact that Dempina is exclusively cultivated in this region, there are neither specific references for its origin nor is it mentioned by ampelographers of the 18th and 19th century. No synonyms of the variety are mentioned for the same reasons, something that is quite unusual for Greek grapevine varieties which are generally accompanied by a number of synonyms. Despite the geographical location of the variety in the PDO zone “Zitsa”, various biotypes or variants (Nerodempina, Repsodempina etc.) have been reported in the greater area of Epirus and western Macedonia. The cultivation of Dempina is recommended for Prefectures of Ioannina, Karditsa, Larissa, Preveza and it is allowed for Prefectures of Thessaloniki and Thesprotia.